Also in that case, chemo agents may be directly infused into liver. If the metastases are more extensive, treatments are aimed to relief symptoms and their effectiveness would vary depending on the situation (eg surgery/radiation for local obstruction, chemo for lung mets...) Chemo is usually a combination of 5-FU and leucovorin for stage C, I'm not sure the exact combination used for stage D. If you would like to know more about the treatments and side effects, I suggest you go have a look at American Cancer Society's website.